mouse ADAM15 Over-expression AAV

Name 
AAV-m-ADAM15
Cat No 
AAV-258517
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Adam15.

AAV-258517
AAV-m-ADAM15

Ready-to-use AAV expressing Mouse Adam15 (a disintegrin and metallopeptidase domain 15 (metargidin)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AD56; MDC15
Description (Vector)
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Gene ID
11490
Gene Name (Vector)
a disintegrin and metallopeptidase domain 15 (metargidin)
Gene Symbol
Adam15
ORF Size (aa)
1347
ORF Size (bp)
1347 bp
RefSeq ID
NM_009614
RefSeq Synonyms
NM_009614, NM_001037722, BC009132,
Species
mouse
UniGene ID
Mm.470104

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.