mouse EFCAB4B Over-expression AAV

Name 
AAV-m-EFCAB4B
Cat No 
AAV-257795
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Cracr2a.

AAV-257795
AAV-m-EFCAB4B

Ready-to-use AAV expressing Mouse Cracr2a (calcium release activated channel regulator 2A). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Efcab4b; Gm1073; Gm462
Description (Vector)
Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Gene ID
381812
Gene Name (Vector)
calcium release activated channel regulator 2A
Gene Symbol
Cracr2a
ORF Size (aa)
933
ORF Size (bp)
933 bp
RefSeq ID
NM_001033464
RefSeq Synonyms
NM_001033464, BC150869,
Species
mouse
UniGene ID
Mm.296093

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.