mouse E2F6 Over-expression AAV

Name 
AAV-m-E2F6
Cat No 
AAV-257659
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse E2f6.

AAV-257659
AAV-m-E2F6

Ready-to-use AAV expressing Mouse E2f6 (E2F transcription factor 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI462434; E2F6a; E2F6b; EMA
Description (Vector)
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F-6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Gene ID
50496
Gene Name (Vector)
E2F transcription factor 6
Gene Symbol
E2f6
ORF Size (aa)
819
ORF Size (bp)
819 bp
RefSeq ID
NM_033270
RefSeq Synonyms
NM_033270, BC057929, BC037656, BC019166,
Species
mouse
UniGene ID
Mm.23296

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.