mouse CISH Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-255518
Availability:
3-5 weeks
Name:
AAV-m-CISH
This is an AAV expressing Mouse Cish.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Cish
- Gene Name
- cytokine inducible SH2-containing protein
- Gene ID
- 12700
- Gene Synonyms
- Cis; CIS-1; CIS1; F17; F23; SOCS
- ORF Size
- 774 bp
- RefSeq#
- BC022178
- Gene Description
- SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
- UniGene ID
- Mm.4592
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