mouse CISH Over-expression AAV

Name 
AAV-m-CISH
Cat No 
AAV-255518
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Cish.

AAV-255518
AAV-m-CISH

Ready-to-use AAV expressing Mouse Cish (cytokine inducible SH2-containing protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Cis; CIS-1; CIS1; F17; F23; SOCS
Description (Vector)
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Gene ID
12700
Gene Name (Vector)
cytokine inducible SH2-containing protein
Gene Symbol
Cish
ORF Size (aa)
774
RefSeq ID
NM_009895
RefSeq Synonyms
NM_009895, NM_001317354, BC022178, BC003783,
Species
mouse
UniGene ID
Mm.4592

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.