mouse AXL Over-expression AAV
This is an AAV expressing Mouse Axl.
AAV-253472
AAV-m-AXL
Ready-to-use AAV expressing Mouse Axl (AXL receptor tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI323647; Ark; Tyro7; Ufo
Description (Vector)
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.
Gene ID
26362
Gene Name (Vector)
AXL receptor tyrosine kinase
Gene Symbol
Axl
ORF Size (aa)
2667
ORF Size (bp)
2667 bp
RefSeq ID
NM_009465
RefSeq Synonyms
NM_009465, NM_001190975, NM_001190974, BC058230, BC050914, BC046618,
Species
mouse
UniGene ID
Mm.4128
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.