mouse METAP2 Over-expression AAV

Name 
AAV-m-METAP2
Cat No 
AAV-251194
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Metap2.

AAV-251194
AAV-m-METAP2

Ready-to-use AAV expressing Mouse Metap2 (methionine aminopeptidase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
4930584B20Rik; A930035J23Rik; AI047573; AL024412; Amp2; AU014659; Mnpep; p67; p67eIF2
Description (Vector)
Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo|Function: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Gene ID
56307
Gene Name (Vector)
methionine aminopeptidase 2
Gene Symbol
Metap2
ORF Size (aa)
1437
ORF Size (bp)
1437 bp
RefSeq ID
NM_019648
RefSeq Synonyms
NM_019648, BC092052, BC002213,
Species
mouse
UniGene ID
Mm.289329

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.