mouse RIPK1 Over-expression AAV

Name 
AAV-m-RIPK1
Cat No 
AAV-251116
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Ripk1.

AAV-251116
AAV-m-RIPK1

Ready-to-use AAV expressing Mouse Ripk1 (receptor (TNFRSF)-interacting serine-threonine kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
D330015H01Rik; Rinp; RIP; Rip1
Description (Vector)
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
Gene ID
19766
Gene Name (Vector)
receptor (TNFRSF)-interacting serine-threonine kinase 1
Gene Symbol
Ripk1
ORF Size (aa)
1971
ORF Size (bp)
1971 bp
RefSeq ID
NM_009068
RefSeq Synonyms
NM_009068, BC058162, BC054542, BC050905,
Species
mouse
UniGene ID
Mm.374799

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.