human DDX5 Over-expression AAV

ATP-dependent RNA helicase DDX5; DEAD (Asp-Glu-Ala-Asp) box helicase 5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD box protein 5; DEAD box-5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD); G17P1; HLR1; HUMP68; p68; probable ATP-dependent RNA helicase DDX5; RNA helicase p68

DDX5 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. Some members of the DEAD box proteins also exhibit functions involved in transcriptional regulation. In addition to a role involved in RNA splicing, DDX5 has been observed to interact with and act as a transcriptional coactivator for estrogen receptor alpha (ERalpha). DDX5 has also been found to interact with CBP/300, Smad3, and p53 to modulate transcription. DDX5 is closely related to and forms heterodimers with DDX17.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.

1655

DEAD-box helicase 5

DEAD-box helicase 5

DDX5

HGNC:2746

9606.0

1845

1845 bp

Probable ATP-dependent RNA helicase DDX5

NM_004396

NM_004396, NM_001320597, NM_001320596, NM_001320595, BC016027,

Apoptosis,Cancer,Cell Cycle,DNA Damage/Repair,Estrogen Signaling,Gene Expression,Helicase Activity,Host-Virus Interactions,Immunology,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Signal Transduction,Spliceosome,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer

cancer,cell_biology,cell_cycle,genetics,transcription_translation,immunology,infectious_disease,signal_transduction

human

DDX5 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. Some members of the DEAD box proteins also exhibit functions involved in transcriptional regulation. In addition to a role involved in RNA splicing, DDX5 has been observed to interact with and act as a transcriptional coactivator for estrogen receptor alpha (ERalpha). DDX5 has also been found to interact with CBP/300, Smad3, and p53 to modulate transcription. DDX5 is closely related to and forms heterodimers with DDX17.

Hs.279806

P17844