human ZAP70 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-228029
Availability:
3-5 weeks
Name:
AAV-h-ZAP70
This is an AAV expressing Human ZAP70.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- ZAP70
- Gene Name
- zeta chain of T cell receptor associated protein kinase 70
- Gene ID
- 7535
- Gene Synonyms
- ADMIO2; IMD48; SRK; STCD; STD; TZK; ZAP-70
- ORF Size
- 1860 bp
- RefSeq#
- BC053878
- Gene Description
- ZAP70 encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
- UniGene ID
- Hs.234569
- HGNC ID
- HGNC:12858
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