human WRAP53 Over-expression AAV
This is an AAV expressing Human WRAP53.
AAV-227842
AAV-h-WRAP53
Ready-to-use AAV expressing Human WRAP53 (WD repeat containing antisense to TP53). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DKCB3; TCAB1; telomerase Cajal body protein 1; WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 protein Wrap53; WD40 repeat-containing protein antisense to TP53; WD40 repeat-containing protein antisense to TP53 gene; WD40 repeat-containing protein encoding RNA antisense to p53; WDR79; WRAP53beta
Description (eCommerce)
WD-repeat domain 79 (WDR79) contains six WD (tryptophan-aspartate) repeat domains found in a number of proteins that function as adaptor molecules in signal transduction and cytoskeletal organization. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. The function of the WDR79 protein has not been characterized, however significant and consistent single nucleotide polymorphisms in the WDR79 gene have been found to be associated with ER negative breast cancer.
Description (Vector)
WRAP53 encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene.
Gene ID
55135
Gene Name (eCommerce)
WD repeat containing antisense to TP53
Gene Name (Vector)
WD repeat containing antisense to TP53
Gene Symbol
WRAP53
HGNC ID
HGNC:25522
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1647
ORF Size (bp)
1647 bp
Protein Name (eCommerce)
Telomerase Cajal body protein 1
RefSeq ID
NM_018081
RefSeq Synonyms
NM_018081, NM_001143992, NM_001143991, NM_001143990, BC002336,
Research Areas
Cell Cycle,RNA Binding,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
WD-repeat domain 79 (WDR79) contains six WD (tryptophan-aspartate) repeat domains found in a number of proteins that function as adaptor molecules in signal transduction and cytoskeletal organization. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. The function of the WDR79 protein has not been characterized, however significant and consistent single nucleotide polymorphisms in the WDR79 gene have been found to be associated with ER negative breast cancer.
UniGene ID
Hs.437460
UniProt ID (eCommerce)
Q9BUR4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.