human WIPI2 Over-expression AAV

Name 
AAV-h-WIPI2
Cat No 
AAV-227796
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human WIPI2.

AAV-227796
AAV-h-WIPI2

Ready-to-use AAV expressing Human WIPI2 (WD repeat domain, phosphoinositide interacting 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ATG18B; Atg21; CGI-50; WD repeat domain phosphoinositide-interacting protein 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI-2; WIPI49-like protein 2
Description (eCommerce)
WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) is an early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P).WIPI2 may bind PtdIns3P. [taken from www.uniprot.org/uniprot/Q9Y4P8].
Description (Vector)
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 (PubMed 15602573)).(supplied by OMIM, Mar 2008)
Gene ID
26100
Gene Name (eCommerce)
WD repeat domain, phosphoinositide interacting 2
Gene Name (Vector)
WD repeat domain, phosphoinositide interacting 2
Gene Symbol
WIPI2
HGNC ID
HGNC:32225
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1365
ORF Size (bp)
1365 bp
Protein Name (eCommerce)
WD repeat domain phosphoinositide-interacting protein 2
RefSeq ID
NM_015610
RefSeq Synonyms
NM_016003, NM_015610, NM_001278299, NM_001033520, NM_001033519, NM_001033518, BC021200, BC007596, BC004116,
Research Areas
Autophagy
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) is an early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P).WIPI2 may bind PtdIns3P. [taken from www.uniprot.org/uniprot/Q9Y4P8].
UniGene ID
Hs.122363
UniProt ID (eCommerce)
Q9Y4P8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.