human WHSC1 Over-expression AAV

Name 
AAV-h-WHSC1
Cat No 
AAV-227781
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NSD2.

AAV-227781
AAV-h-WHSC1

Ready-to-use AAV expressing Human NSD2 (nuclear receptor binding SET domain protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; KMT3F; KMT3G; MMSET; multiple myeloma SET domain containing protein type III; Multiple myeloma SET domain-containing protein; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; REIIBP; trithorax/ash1-related protein 5; TRX5; WHS; WHSC1; Wolf-Hirschhorn syndrome candidate 1; Wolf-Hirschhorn syndrome candidate 1 protein
Description (eCommerce)
MMSET (multiple myeloma SET domain-containing protein) or NSD2 (nuclear SET-domain containing protein 2) is the product of the Wolf-Hirschhorn syndrome candidate 1 (WHSC1) gene. MMSET is a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development and is a probable histone methyltransferase. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4 [taken from NCBI Entrez Gene (Gene ID: 7468].
Description (Vector)
WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. WHSC1 maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
Gene ID
7468
Gene Name (eCommerce)
nuclear receptor binding SET domain protein 2
Gene Name (Vector)
nuclear receptor binding SET domain protein 2
Gene Symbol
NSD2
HGNC ID
HGNC:12766
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4098
ORF Size (bp)
4098 bp
Protein Name (eCommerce)
Histone-lysine N-methyltransferase NSD2
RefSeq ID
NM_007331
RefSeq Synonyms
NM_133335, NM_133334, NM_133331, NM_133330, NM_007331, NM_001042424, BC166668, BC152412,
Research Areas
Cancer,Cardiology,Cell Biology,Histone Modification,Metabolism/Metabolic Process,Methyltransferase,Neurobiology,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Translational Control,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,metabolism,neurobiology,transcription_translation
Species
human
Target Sentence
MMSET (multiple myeloma SET domain-containing protein) or NSD2 (nuclear SET-domain containing protein 2) is the product of the Wolf-Hirschhorn syndrome candidate 1 (WHSC1) gene. MMSET is a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development and is a probable histone methyltransferase. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4 [taken from NCBI Entrez Gene (Gene ID: 7468].
UniGene ID
Hs.113876
UniProt ID (eCommerce)
O96028

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Ad-h-WHSC1

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.