human WDR4 Over-expression AAV

Name 
AAV-h-WDR4
Cat No 
AAV-227671
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human WDR4.

AAV-227671
AAV-h-WDR4

Ready-to-use AAV expressing Human WDR4 (WD repeat domain 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
TRM82; TRM82 tRNA methyltransferase 82 homolog; TRMT82; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4; WD repeat-containing protein 4
Description (eCommerce)
WDR4 (WD repeat-containing protein 4) was identified in a search for candidate genes involved in the development of Down syndrome phenotypes. It is required for the 7-methylguanosine (m7G)-methyltransferase activity for tRNA. WDR bears two WD repeats. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation.
Description (Vector)
WDR4 encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR4 is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene.
Gene ID
10785
Gene Name (eCommerce)
WD repeat domain 4
Gene Name (Vector)
WD repeat domain 4
Gene Symbol
WDR4
HGNC ID
HGNC:12756
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
801
Protein Name (eCommerce)
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
RefSeq ID
NM_018669
RefSeq Synonyms
NM_033661, NM_018669, NM_001260477, NM_001260476, NM_001260475, NM_001260474, BC006341, BC001074,
Research Areas
Neurobiology,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,neurobiology,transcription_translation
Species
human
Target Sentence
WDR4 (WD repeat-containing protein 4) was identified in a search for candidate genes involved in the development of Down syndrome phenotypes. It is required for the 7-methylguanosine (m7G)-methyltransferase activity for tRNA. WDR bears two WD repeats. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation.
UniGene ID
Hs.248815
UniProt ID (eCommerce)
P57081

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.