human VKORC1 Over-expression AAV
This is an AAV expressing Human VKORC1.
AAV-227487
AAV-h-VKORC1
Ready-to-use AAV expressing Human VKORC1 (vitamin K epoxide reductase complex subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EDTP308; MST134; MST576; VKCFD2; VKOR
Description (Vector)
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.
Gene ID
79001
Gene Name (Vector)
vitamin K epoxide reductase complex subunit 1
Gene Symbol
VKORC1
HGNC ID
HGNC:23663
ORF Size (aa)
492
RefSeq ID
NM_206824
RefSeq Synonyms
NM_206824, NM_024006, NM_001311311, BC002911,
Species
human
UniGene ID
Hs.324844
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.