human VASP Over-expression AAV
This is an AAV expressing Human VASP.
AAV-227405
AAV-h-VASP
Ready-to-use AAV expressing Human VASP (vasodilator-stimulated phosphoprotein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
vasodilator-stimulated phosphoprotein; VASP
Description (eCommerce)
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG [taken from NCBI Entrez Gene (Gene ID: 7408)].
Description (Vector)
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
Gene ID
7408
Gene Name (eCommerce)
vasodilator stimulated phosphoprotein
Gene Name (Vector)
vasodilator-stimulated phosphoprotein
Gene Symbol
VASP
HGNC ID
HGNC:12652
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1143
Protein Name (eCommerce)
Vasodilator-stimulated phosphoprotein
RefSeq ID
NM_003370
RefSeq Synonyms
NM_003370, BC038224, BC026019,
Research Areas
Axon Guidance,Cytoskeleton,EGFR Signaling,Immunology,Interleukin Signaling,Neurobiology,Neurodevelopment,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,neurobiology,cell_biology,signal_transduction,immunology,neurobiology,developmental_biology,signal_transduction,immunology
Species
human
Target Sentence
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG [taken from NCBI Entrez Gene (Gene ID: 7408)].
UniGene ID
Hs.515469
UniProt ID (eCommerce)
P50552
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.