human UIMC1 Over-expression AAV

Name
AAV-h-UIMC1

Cat No
AAV-227168

Availability
4-5 weeks

This is an AAV expressing Human UIMC1.

AAV-227168

AAV-h-UIMC1

Ready-to-use AAV expressing Human UIMC1 (ubiquitin interaction motif containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BRCA1-A complex subunit RAP80; RAP80; receptor-associated protein 80; retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1; X2HRIP110

Description (eCommerce)

RAP80 was first identified as a nuclear protein that interacts with the retinoid-related testis-associated receptor (RTR) and is able to inhibit the interaction of RTR with the N-CoR co-repressor. RAP80 has also been shown to interact with estrogen receptor alpha (ER-alpha) and modulate its activity. The modulation of ER-alpha activity is dependent on the ubiquitin-interacting motif (UIM) of RAP80. The UIM of RAP80 has also been demonstrated to be important for the BRCA1-dependent DNA repair response.

Gene ID

51720

Gene Name (eCommerce)

ubiquitin interaction motif containing 1

Gene Name (Vector)

ubiquitin interaction motif containing 1

Gene Symbol

UIMC1

HGNC ID

HGNC:30298

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1158

ORF Size (bp)

1158 bp

Protein Name (eCommerce)

BRCA1-A complex subunit RAP80

RefSeq ID

NM_016290

RefSeq Synonyms

NM_016290, NM_001317961, NM_001199298, NM_001199297, BC032561, BC006078,

Research Areas

Cell Cycle,DNA Damage/Repair,Histone Modification,Homologous Recombination,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation

Species

human

Target Sentence

RAP80 was first identified as a nuclear protein that interacts with the retinoid-related testis-associated receptor (RTR) and is able to inhibit the interaction of RTR with the N-CoR co-repressor. RAP80 has also been shown to interact with estrogen receptor alpha (ER-alpha) and modulate its activity. The modulation of ER-alpha activity is dependent on the ubiquitin-interacting motif (UIM) of RAP80. The UIM of RAP80 has also been demonstrated to be important for the BRCA1-dependent DNA repair response.

UniGene ID

Hs.232721

UniProt ID (eCommerce)

Q96RL1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.