human TXNIP Over-expression AAV

Name 
AAV-h-TXNIP
Cat No 
AAV-226923
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TXNIP.

AAV-226923
AAV-h-TXNIP

Ready-to-use AAV expressing Human TXNIP (thioredoxin interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ARRDC6; EST01027; HHCPA78; THIF; thioredoxin binding protein 2; Thioredoxin-binding protein 2; thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1; vitamin D3 up-regulated protein 1
Description (eCommerce)
Thioredoxin-interacting protein (TXNIP) may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. TXNIP interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Also, TXNIP functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H3M7].
Gene ID
10628
Gene Name (eCommerce)
thioredoxin interacting protein
Gene Name (Vector)
thioredoxin interacting protein
Gene Symbol
TXNIP
HGNC ID
HGNC:16952
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1176
ORF Size (bp)
1176 bp
Protein Name (eCommerce)
Thioredoxin-interacting protein
RefSeq ID
NM_006472
RefSeq Synonyms
NM_006472, NM_001313972, BC093704, BC093702,
Research Areas
Apoptosis,Cancer,Cell Cycle,Immunology,Innate Immunity,Signal Transduction,TNF Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,immunology,signal_transduction
Species
human
Target Sentence
Thioredoxin-interacting protein (TXNIP) may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. TXNIP interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Also, TXNIP functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H3M7].
UniGene ID
Hs.715525
UniProt ID (eCommerce)
Q9H3M7

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.