human TSEPA Over-expression AAV

Name 
AAV-h-TSEPA
Cat No 
AAV-226595
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human THEMIS.

AAV-226595
AAV-h-TSEPA

Ready-to-use AAV expressing Human THEMIS (thymocyte selection associated). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C6orf190; C6orf207; GASP; GRB2-associated protein; protein THEMIS; signaling phosphoprotein specific for T cells; SPOT; thymocyte selection pathway associated; thymocyte-expressed molecule involved in selection; TSEPA
Description (eCommerce)
Thymocyte-expressed molecule involved in selection (THEMIS) plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells [taken from NCBI Entrez Gene (Gene ID: 387357)].
Description (Vector)
THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.
Gene ID
387357
Gene Name (eCommerce)
thymocyte selection associated
Gene Name (Vector)
thymocyte selection associated
Gene Symbol
THEMIS
HGNC ID
HGNC:21569
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1926
ORF Size (bp)
1926 bp
Protein Name (eCommerce)
Protein THEMIS
RefSeq ID
NM_001318531
RefSeq Synonyms
NM_001318531, NM_001164687, NM_001164685, NM_001010923, BC130516,
Research Areas
Immunology,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
Thymocyte-expressed molecule involved in selection (THEMIS) plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells [taken from NCBI Entrez Gene (Gene ID: 387357)].
UniGene ID
Hs.661756
UniProt ID (eCommerce)
Q8N1K5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.