human TRIM3 Over-expression AAV

Name 
AAV-h-TRIM3
Cat No 
AAV-226423
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TRIM3.

AAV-226423
AAV-h-TRIM3

Ready-to-use AAV expressing Human TRIM3 (tripartite motif containing 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BERP; brain expressed ring finger; brain-expressed RING finger protein; HAC1; ring finger protein 22; RING finger protein 97; RNF22; RNF97; tripartite motif protein TRIM3; tripartite motif-containing protein 3
Description (eCommerce)
TRIM3/BERP is a member of the tripartite motif RBCC/Trim domain family that contains a RING-finger domain, B-boxes, and an alpha-helical coiled-coil region. TRIM3/BERP has been identified as a component of the CART (cytoskeleton-associated recycling or transport) complex which includes actinin-4, hrs, myosin V, and TRIM3/BERP. In this complex TRIM/BERP is involved in the recycling of plasma membrane receptors.
Description (Vector)
TRIM3 is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.
Gene ID
10612
Gene Name (eCommerce)
tripartite motif containing 3
Gene Name (Vector)
tripartite motif containing 3
Gene Symbol
TRIM3
HGNC ID
HGNC:10064
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2235
ORF Size (bp)
2235 bp
Protein Name (eCommerce)
Tripartite motif-containing protein 3
RefSeq ID
NM_006458
RefSeq Synonyms
NM_033278, NM_006458, NM_001248007, NM_001248006, BC096827,
Research Areas
DNA Damage/Repair,Neurobiology,Neurodevelopment,Zinc-finger
Research Areas (Faceted)
genetics,transcription_translation,neurobiology,developmental_biology,cell_biology
Species
human
Target Sentence
TRIM3/BERP is a member of the tripartite motif RBCC/Trim domain family that contains a RING-finger domain, B-boxes, and an alpha-helical coiled-coil region. TRIM3/BERP has been identified as a component of the CART (cytoskeleton-associated recycling or transport) complex which includes actinin-4, hrs, myosin V, and TRIM3/BERP. In this complex TRIM/BERP is involved in the recycling of plasma membrane receptors.
UniGene ID
Hs.591992
UniProt ID (eCommerce)
O75382

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.