human TRIM28 Over-expression AAV

Name 
AAV-h-TRIM28
Cat No 
AAV-226419
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TRIM28.

AAV-226419
AAV-h-TRIM28

Ready-to-use AAV expressing Human TRIM28 (tripartite motif containing 28). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
E3 SUMO-protein ligase TRIM28; KAP1; KAP-1; KRAB Kruppel-associated box domain-associated protein 1; KRAB-associated protein 1; KRAB-interacting protein 1; KRIP-1; nuclear corepressor KAP-1; PPP1R157; protein phosphatase 1, regulatory subunit 157; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; RNF96; TF1B; TIF1B; TIF1-beta; transcription intermediary factor 1-beta; transcriptional intermediary factor 1-beta; Tripartite motif-containing protein 28
Description (eCommerce)
KAP-1 (KRAB-Associated Protein 1) is a member of the tripartite motif RBCC/Trim domain family that contains a RING finger domain, B boxes, and an alpha helical coiled coil region. KAP-1 functions as a corepressor by interacting with the KRAB domain of KRAB zinc-finger transcriptional repressors. KAP-1 also appears to function as a scaffold for chromatin-remodeling complexes involved in transcriptional repression.
Description (Vector)
TRIM28 mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Gene ID
10155
Gene Name (eCommerce)
tripartite motif containing 28
Gene Name (Vector)
tripartite motif containing 28
Gene Symbol
TRIM28
HGNC ID
HGNC:16384
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2262
ORF Size (bp)
2262 bp
Protein Name (eCommerce)
Transcription intermediary factor 1-beta
RefSeq ID
NM_005762
RefSeq Synonyms
NM_005762, BC052986, BC004978,
Research Areas
Chromatin Remodeling,DNA Damage/Repair,Gene Expression,Kinase/Phosphatase,p53 Signaling,Phospho-specific,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,signal_transduction
Species
human
Target Sentence
KAP-1 (KRAB-Associated Protein 1) is a member of the tripartite motif RBCC/Trim domain family that contains a RING finger domain, B boxes, and an alpha helical coiled coil region. KAP-1 functions as a corepressor by interacting with the KRAB domain of KRAB zinc-finger transcriptional repressors. KAP-1 also appears to function as a scaffold for chromatin-remodeling complexes involved in transcriptional repression.
UniGene ID
Hs.467408
UniProt ID (eCommerce)
Q13263

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.