human TRAFD1 Over-expression AAV

Name 
AAV-h-TRAFD1
Cat No 
AAV-226335
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TRAFD1.

AAV-226335
AAV-h-TRAFD1

Ready-to-use AAV expressing Human TRAFD1 (TRAF-type zinc finger domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FLN29; FLN29 gene product; Protein FLN29; TRAF-type zinc finger domain-containing protein 1
Description (eCommerce)
FLN29 is a negative feedback regulator that controls excessive innate immune responses. It regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. FLN29 may inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation It may negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14545].
Description (Vector)
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 (PubMed 18849341)).(supplied by OMIM, Dec 2009)
Gene ID
10906
Gene Name (eCommerce)
TRAF-type zinc finger domain containing 1
Gene Name (Vector)
TRAF-type zinc finger domain containing 1
Gene Symbol
TRAFD1
HGNC ID
HGNC:24808
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1749
ORF Size (bp)
1749 bp
Protein Name (eCommerce)
TRAF-type zinc finger domain-containing protein 1
RefSeq ID
NM_006700
RefSeq Synonyms
NM_006700, NM_001143906, BC003553,
Research Areas
Immunology,Signal Transduction,Toll-like Receptor Signaling,Zinc-finger
Research Areas (Faceted)
signal_transduction,immunology,cell_biology
Species
human
Target Sentence
FLN29 is a negative feedback regulator that controls excessive innate immune responses. It regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. FLN29 may inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation It may negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14545].
UniGene ID
Hs.5148
UniProt ID (eCommerce)
O14545

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.