human THOP1 Over-expression AAV

Name 
AAV-h-THOP1
Cat No 
AAV-225458
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human THOP1.

AAV-225458
AAV-h-THOP1

Ready-to-use AAV expressing Human THOP1 (thimet oligopeptidase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
endopeptidase 24.15; EP24.15; MEPD_HUMAN; MP78; thimet oligopeptidase; TOP
Description (eCommerce)
Thimet oligopeptidase (THOP1) is a kininase that uses zinc as a cofactor. THOP1 cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. THOP1 also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides [taken from NCBI Entrez Gene (Gene ID: 7064)].
Gene ID
7064
Gene Name (eCommerce)
thimet oligopeptidase 1
Gene Name (Vector)
thimet oligopeptidase 1
Gene Symbol
THOP1
HGNC ID
HGNC:11793
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2070
ORF Size (bp)
2070 bp
Protein Name (eCommerce)
Thimet oligopeptidase
RefSeq ID
NM_003249
RefSeq Synonyms
NM_003249, BC013878, BC002391, BC000135,
Research Areas
Signal Transduction
Research Areas (Faceted)
signal_transduction
Species
human
Target Sentence
Thimet oligopeptidase (THOP1) is a kininase that uses zinc as a cofactor. THOP1 cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. THOP1 also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides [taken from NCBI Entrez Gene (Gene ID: 7064)].
UniGene ID
Hs.78769
UniProt ID (eCommerce)
P52888

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.