human THOC4 Over-expression AAV
This is an AAV expressing Human ALYREF.
AAV-225453
AAV-h-THOC4
Ready-to-use AAV expressing Human ALYREF (Aly/REF export factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ally of AML-1 and LEF-1; ALY; ALY/REF; Aly/REF export factor; BEF; bZIP enhancing factor; bZIP-enhancing factor BEF; REF; THO complex 4; THO complex subunit 4; tho4; THOC4; transcriptional coactivator Aly/REF
Description (eCommerce)
Aly (ally of AML-1 and LEF-1) is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. Aly also functions as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Additionally, Aly plays a role in mRNA processing and export and may function as scaffold that mediates interactions between proteins and/or RNA. Aly is also part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay. Aly directs mRNA derived from Herpes simplex virus intron-less genes to the NXF1-mediated export pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q886V81].
Description (Vector)
ALYREF is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.
Gene ID
10189
Gene Name (eCommerce)
Aly/REF export factor
Gene Name (Vector)
Aly/REF export factor
Gene Symbol
ALYREF
HGNC ID
HGNC:19071
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
774
ORF Size (bp)
774 bp
Protein Name (eCommerce)
THO complex subunit 4
RefSeq ID
NM_005782
RefSeq Synonyms
NM_005782, BC052302,
Research Areas
Gene Expression,Host-Virus Interactions,mRNA Processing,mRNA Splicing,mRNA Transport,RNA Binding,RNA Processing,RNA Transport,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,infectious_disease,cell_biology
Species
human
Target Sentence
Aly (ally of AML-1 and LEF-1) is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. Aly also functions as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Additionally, Aly plays a role in mRNA processing and export and may function as scaffold that mediates interactions between proteins and/or RNA. Aly is also part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay. Aly directs mRNA derived from Herpes simplex virus intron-less genes to the NXF1-mediated export pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q886V81].
UniGene ID
Hs.534385
UniProt ID (eCommerce)
Q86V81
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.