human TDO2 Over-expression AAV

Name
AAV-h-TDO2

Cat No
AAV-225263

Availability
4-5 weeks

This is an AAV expressing Human TDO2.

AAV-225263

AAV-h-TDO2

Ready-to-use AAV expressing Human TDO2 (tryptophan 2,3-dioxygenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

TDO; TO; TPH2; TRPO

Description (Vector)

TDO2 encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Gene ID

6999

Gene Name (Vector)

tryptophan 2,3-dioxygenase

Gene Symbol

TDO2

HGNC ID

HGNC:11708

ORF Size (aa)

1221

ORF Size (bp)

1221 bp

RefSeq ID

NM_005651

RefSeq Synonyms

NM_005651, BC005355,

Species

human

UniGene ID

Hs.183671

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.