human TBX21 Over-expression AAV

Name 
AAV-h-TBX21
Cat No 
AAV-225158
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TBX21.

AAV-225158
AAV-h-TBX21

Ready-to-use AAV expressing Human TBX21 (T-box 21). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
TBET; T-bet; TBLYM; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM
Description (eCommerce)
T-bet/TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX21 is a lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and activating transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. [taken from NCBI Entrez Gene (Gene ID: 30009)].
Description (Vector)
TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX21 is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
Gene ID
30009
Gene Name (eCommerce)
T-box 21
Gene Name (Vector)
T-box 21
Gene Symbol
TBX21
HGNC ID
HGNC:11599
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1608
ORF Size (bp)
1608 bp
Protein Name (eCommerce)
T-box transcription factor TBX21
RefSeq ID
NM_013351
RefSeq Synonyms
NM_013351, BC039739,
Research Areas
Host-Virus Interactions,Immunology,Interleukin Signaling,Neurobiology,Response to Virus,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
T-bet/TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX21 is a lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and activating transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. [taken from NCBI Entrez Gene (Gene ID: 30009)].
UniGene ID
Hs.272409
UniProt ID (eCommerce)
Q9UL17

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.