human SSRP1 Over-expression AAV

Name 
AAV-h-SSRP1
Cat No 
AAV-224400
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SSRP1.

AAV-224400
AAV-h-SSRP1

Ready-to-use AAV expressing Human SSRP1 (structure specific recognition protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
chromatin-specific transcription elongation factor 80 kDa subunit; cisplatin-DNA SSRP; facilitates chromatin remodeling 80 kDa subunit; facilitates chromatin transcription complex 80 kDa subunit; facilitates chromatin transcription complex subunit SSRP1; FACT; FACT 80 kDa subunit; FACT complex subunit SSRP1; FACT80; FACTp80; high mobility group box; hSSRP1; recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; T160
Description (eCommerce)
Structure specific recognition protein 1 (SSRP1) is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. SSRP1 also functions as a co-activator of the transcriptional activator p63 [taken from NCBI Entrez Gene (Gene ID: 6749].
Description (Vector)
SSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
Gene ID
6749
Gene Name (eCommerce)
structure specific recognition protein 1
Gene Name (Vector)
structure specific recognition protein 1
Gene Symbol
SSRP1
HGNC ID
HGNC:11327
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2130
ORF Size (bp)
2130 bp
Protein Name (eCommerce)
FACT complex subunit SSRP1
RefSeq ID
NM_003146
RefSeq Synonyms
NM_003146, BC005116,
Research Areas
DNA Damage/Repair,DNA Replication,Gene Expression,Host-Virus Interactions,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,transcription_translation
Species
human
Target Sentence
Structure specific recognition protein 1 (SSRP1) is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. SSRP1 also functions as a co-activator of the transcriptional activator p63 [taken from NCBI Entrez Gene (Gene ID: 6749].
UniGene ID
Hs.523680
UniProt ID (eCommerce)
Q08945

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.