human SSH1 Over-expression AAV

Name 
AAV-h-SSH1
Cat No 
AAV-224391
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SSH1.

AAV-224391
AAV-h-SSH1

Ready-to-use AAV expressing Human SSH1 (slingshot protein phosphatase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hSSH-1L; protein phosphatase Slingshot homolog 1; slingshot homolog 1; SSH1L; SSH-1L; SSH-like protein 1
Description (eCommerce)
SSH1, also known as slingshot, is a phosphatase that functions to activate the actin severing protein, ADF/cofilin, and influence actin dynamics. There are three members of the slingshot family, SSH1, SSH2, and SSH3. SSH1 has been shown to function downstream of alpha6beta4 integrin/Rac1 signaling in conjunction with 14-3-3 association.
Description (Vector)
SSH1 belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
54434
Gene Name (eCommerce)
slingshot protein phosphatase 1
Gene Name (Vector)
slingshot protein phosphatase 1
Gene Symbol
SSH1
HGNC ID
HGNC:30579
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3150
ORF Size (bp)
3150 bp
Protein Name (eCommerce)
Protein phosphatase Slingshot homolog 1
RefSeq ID
NM_018984
RefSeq Synonyms
NM_018984, NM_001161331, NM_001161330, BC062341,
Research Areas
Axonogenesis,Cytoskeleton,FGF Signaling,Kinase/Phosphatase,Neurobiology,Phosphatase,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology,cell_biology,signal_transduction,developmental_biology,cell_biology,neurobiology
Species
human
Target Sentence
SSH1, also known as slingshot, is a phosphatase that functions to activate the actin severing protein, ADF/cofilin, and influence actin dynamics. There are three members of the slingshot family, SSH1, SSH2, and SSH3. SSH1 has been shown to function downstream of alpha6beta4 integrin/Rac1 signaling in conjunction with 14-3-3 association.
UniGene ID
Hs.199763
UniProt ID (eCommerce)
Q8WYL5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.