human EIF4G2 Over-expression AAV

Name 
AAV-h-EIF4G2
Cat No 
AAV-223853
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human EIF4G2.

AAV-223853
AAV-h-EIF4G2

Ready-to-use AAV expressing Human EIF4G2 (eukaryotic translation initiation factor 4 gamma 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AAG1; aging-associated protein 1; DAP5; DAP-5; death-associated protein 5; eIF4G 2; eIF-4G 2; eIF-4-gamma 2; eukaryotic translation initiation factor 4 gamma 2; eukaryotic translation initiation factor 4G-like 1; NAT1; P97
Description (eCommerce)
DAP5 (death associated protein 5) is also known as eukaryotic translation initiation factor 4 gamma 2. DAP5 has been found to function as a general repressor of translation and appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis, and viral infection.
Description (Vector)
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Gene ID
1982
Gene Name (eCommerce)
eukaryotic translation initiation factor 4 gamma 2
Gene Name (Vector)
eukaryotic translation initiation factor 4 gamma 2
Gene Symbol
EIF4G2
HGNC ID
HGNC:3297
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2106
ORF Size (bp)
2106 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 4 gamma 2
RefSeq ID
NM_001418
RefSeq Synonyms
NM_001418, NM_001172705, NM_001042559, BC111548, BC111415, BC065276, BC043149, BC039851, BC018975, BC018746,
Research Areas
Apoptosis,Cardiology,Cardiovascular,Cell Cycle,Cytokine Signaling,Host-Virus Interactions,IFN Signaling,Immunology,RNA Processing,RNA Transport,Signal Transduction,Translational Control
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,genetics,transcription_translation,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
DAP5 (death associated protein 5) is also known as eukaryotic translation initiation factor 4 gamma 2. DAP5 has been found to function as a general repressor of translation and appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis, and viral infection.
UniGene ID
Hs.183684
UniProt ID (eCommerce)
P78344

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.