human SIGLEC8 Over-expression AAV

Name 
AAV-h-SIGLEC8
Cat No 
AAV-222995
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SIGLEC8.

AAV-222995
AAV-h-SIGLEC8

Ready-to-use AAV expressing Human SIGLEC8 (sialic acid binding Ig like lectin 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SAF2; SIGLEC-8; SIGLEC8L
Description (Vector)
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 (PubMed 11095983)).(supplied by OMIM, May 2010)
Gene ID
27181
Gene Name (Vector)
sialic acid binding Ig like lectin 8
Gene Symbol
SIGLEC8
HGNC ID
HGNC:10877
ORF Size (aa)
1500
ORF Size (bp)
1500 bp
RefSeq ID
NM_014442
RefSeq Synonyms
NM_014442, BC053319,
Species
human
UniGene ID
Hs.447899

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.