human SHOX2 Over-expression AAV

Name
AAV-h-SHOX2

Cat No
AAV-222959

Availability
4-5 weeks

This is an AAV expressing Human SHOX2.

AAV-222959

AAV-h-SHOX2

Ready-to-use AAV expressing Human SHOX2 (short stature homeobox 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

OG12; OG12X; SHOT

Description (Vector)

SHOX2 is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. SHOX2 is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants.

Gene ID

6474

Gene Name (Vector)

short stature homeobox 2

Gene Symbol

SHOX2

HGNC ID

HGNC:10854

ORF Size (aa)

1068

RefSeq ID

NM_003030

RefSeq Synonyms

NM_006884, NM_003030, NM_001163678, BC008829,

Species

human

UniGene ID

Hs.55967

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.