human SHARPIN Over-expression AAV

Name 
AAV-h-SHARPIN
Cat No 
AAV-222924
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SHARPIN.

AAV-222924
AAV-h-SHARPIN

Ready-to-use AAV expressing Human SHARPIN (SHANK associated RH domain interactor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hSIPL1; shank-associated RH domain-interacting protein; shank-interacting protein-like 1; sharpin; SIPL1
Description (eCommerce)
Sharpin (Shank-associated RH domain-interacting protein) is a component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0F6].
Gene ID
81858
Gene Name (eCommerce)
SHANK associated RH domain interactor
Gene Name (Vector)
SHANK associated RH domain interactor
Gene Symbol
SHARPIN
HGNC ID
HGNC:25321
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1164
ORF Size (bp)
1164 bp
Protein Name (eCommerce)
Sharpin
RefSeq ID
NM_030974
RefSeq Synonyms
NM_030974, BC034028, BC025244,
Research Areas
Apoptosis,Brain Development,Cancer,CD40 Signaling,Immunology,Neurobiology,Neurodevelopment,NF-kB Signaling,Signal Transduction,Synapse,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Sharpin (Shank-associated RH domain-interacting protein) is a component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0F6].
UniGene ID
Hs.529755
UniProt ID (eCommerce)
Q9H0F6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.