human SETMAR Over-expression AAV

Name 
AAV-h-SETMAR
Cat No 
AAV-222744
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SETMAR.

AAV-222744
AAV-h-SETMAR

Ready-to-use AAV expressing Human SETMAR (SET domain and mariner transposase fusion gene). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Histone-lysine N-methyltransferase; histone-lysine N-methyltransferase SETMAR; Mar1; METNASE; SET domain and mariner transposase fusion gene-containing protein; SET domain and mariner transposase fusion protein
Description (eCommerce)
Metnase is also known as Histone-lysine N-methyltransferase SETMAR. Metnase is a histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Metanase specifically mediates dimethylation of H3 'Lys-36', and has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Metnase possessess DNA nicking activity and in vivo end joining activity, and it may mediate genomic integration of foreign DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q53H47].
Gene ID
6419
Gene Name (eCommerce)
SET domain and mariner transposase fusion gene
Gene Name (Vector)
SET domain and mariner transposase fusion gene
Gene Symbol
SETMAR
HGNC ID
HGNC:10762
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1059
ORF Size (bp)
1059 bp
Protein Name (eCommerce)
Histone-lysine N-methyltransferase SETMAR
RefSeq ID
NM_006515
RefSeq Synonyms
NM_006515, NM_001320678, NM_001320677, NM_001320676, NM_001276325, NM_001243723, BC011635,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Damage/Repair,Histone Modification,Methyltransferase,Neurobiology
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,neurobiology
Species
human
Target Sentence
Metnase is also known as Histone-lysine N-methyltransferase SETMAR. Metnase is a histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Metanase specifically mediates dimethylation of H3 'Lys-36', and has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Metnase possessess DNA nicking activity and in vivo end joining activity, and it may mediate genomic integration of foreign DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q53H47].
UniGene ID
Hs.475300
UniProt ID (eCommerce)
Q53H47

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.