human SERPINI1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-222714
Availability:
3-5 weeks
Name:
AAV-h-SERPINI1
This is an AAV expressing Human SERPINI1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- SERPINI1
- Gene Name
- serpin family I member 1
- Gene ID
- 5274
- Gene Synonyms
- neuroserpin; PI12
- ORF Size
- 1233 bp
- RefSeq#
- BC018043
- Gene Description
- SERPINI1 encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
- UniGene ID
- Hs.478153
- HGNC ID
- HGNC:8943
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