human RRM2B Over-expression AAV

Name 
AAV-h-RRM2B
Cat No 
AAV-222005
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RRM2B.

AAV-222005
AAV-h-RRM2B

Ready-to-use AAV expressing Human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MTDPS8A; MTDPS8B; P53R2
Description (Vector)
RRM2B encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.
Gene ID
50484
Gene Name (Vector)
ribonucleotide reductase regulatory TP53 inducible subunit M2B
Gene Symbol
RRM2B
HGNC ID
HGNC:17296
ORF Size (aa)
1056
ORF Size (bp)
1056 bp
RefSeq ID
NM_015713
RefSeq Synonyms
NM_015713, NM_001172478, NM_001172477, BC130628, BC117496, BC108261,
Species
human
UniGene ID
Hs.512592

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.