human RPS6KA5 Over-expression AAV

Name 
AAV-h-RPS6KA5
Cat No 
AAV-221939
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RPS6KA5.

AAV-221939
AAV-h-RPS6KA5

Ready-to-use AAV expressing Human RPS6KA5 (ribosomal protein S6 kinase A5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
90 kDa ribosomal protein S6 kinase 5; MSK1; MSPK1; nuclear mitogen- and stress-activated protein kinase 1; ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; RLPK; RSKL; RSK-like protein kinase; S6K-alpha-5
Description (eCommerce)
MSK1 is a serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). MSK1 Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. MSK1 also phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75582].
Gene ID
9252
Gene Name (eCommerce)
ribosomal protein S6 kinase A5
Gene Name (Vector)
ribosomal protein S6 kinase A5
Gene Symbol
RPS6KA5
HGNC ID
HGNC:10434
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1650
ORF Size (bp)
1650 bp
Protein Name (eCommerce)
Ribosomal protein S6 kinase alpha-5
RefSeq ID
NM_004755
RefSeq Synonyms
NM_182398, NM_004755, NM_001322238, NM_001322237, NM_001322236, NM_001322235, NM_001322234, NM_001322233, NM_001322232, NM_001322231, NM_001322230, NM_001322229, NM_001322228, NM_001322227, BC017187,
Research Areas
Axon Guidance,BDNF Signaling,Bladder Cancer,Cancer,EGFR Signaling,Histone Modification,IFN Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Kinase/Phosphatase,MAPK Signaling,MicroRNAs in Cancer,Neurobiology,NGF Signaling,Signal Transduction,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,genetics,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
MSK1 is a serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). MSK1 Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. MSK1 also phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75582].
UniGene ID
Hs.510225
UniProt ID (eCommerce)
O75582

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AAV-h-RPS6KA6

Cat No: AAV-221940

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.