human RPA2 Over-expression AAV

Name 
AAV-h-RPA2
Cat No 
AAV-221532
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RPA2.

AAV-221532
AAV-h-RPA2

Ready-to-use AAV expressing Human RPA2 (replication protein A2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
REPA2; replication factor A protein 2; replication protein A 32 kDa subunit; replication protein A 34 kDa subunit; RF-A protein 2; RP-A p32; RP-A p34; RPA32
Description (eCommerce)
Replication protein A (RPA) is a multisubunit complex that carries out DNA mismatch repair (MMR) in association with MSH2 (a subunit of human MutS heterodimers), MLH1 (a subunit of human MutL heterodimers), PCNA, and DNA polymerase-delta. RPA is composed of a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA2, the 32kDa subunit, is phosphorylated by the cdc2 family of kinases when cells enter S-phase and in response to DNA damage by ATM, ATR, and DNA-PK.
Gene ID
6118
Gene Name (eCommerce)
replication protein A2
Gene Name (Vector)
replication protein A2
Gene Symbol
RPA2
HGNC ID
HGNC:10290
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
813
ORF Size (bp)
813 bp
Protein Name (eCommerce)
Replication protein A 32 kDa subunit
RefSeq ID
NM_002946
RefSeq Synonyms
NM_002946, NM_001297558, NM_001286076, BC021257, BC012157, BC001630,
Research Areas
Cell Cycle,DNA Damage/Repair,DNA Replication,Fanconi anemia,Homologous Recombination,Neurobiology,Phospho-specific,Replication,Signal Transduction,Telomeric Maintenance
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,neurobiology,cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Replication protein A (RPA) is a multisubunit complex that carries out DNA mismatch repair (MMR) in association with MSH2 (a subunit of human MutS heterodimers), MLH1 (a subunit of human MutL heterodimers), PCNA, and DNA polymerase-delta. RPA is composed of a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA2, the 32kDa subunit, is phosphorylated by the cdc2 family of kinases when cells enter S-phase and in response to DNA damage by ATM, ATR, and DNA-PK.
UniGene ID
Hs.79411
UniProt ID (eCommerce)
P15927

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.