human RDH12 Over-expression AAV

Name 
AAV-h-RDH12
Cat No 
AAV-220964
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RDH12.

AAV-220964
AAV-h-RDH12

Ready-to-use AAV expressing Human RDH12 (retinol dehydrogenase 12 (all-trans/9-cis/11-cis)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LCA13; RP53; SDR7C2
Description (Vector)
RDH12 is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).
Gene ID
145226
Gene Name (Vector)
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
Gene Symbol
RDH12
HGNC ID
HGNC:19977
ORF Size (aa)
951
RefSeq ID
NM_152443
RefSeq Synonyms
NM_152443, BC025724,
Species
human
UniGene ID
Hs.415322

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.