human RCAN1 Over-expression AAV

Name
AAV-h-RCAN1

Cat No
AAV-220931

Availability
4-5 weeks

This is an AAV expressing Human RCAN1.

AAV-220931

AAV-h-RCAN1

Ready-to-use AAV expressing Human RCAN1 (regulator of calcineurin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1

Description (Vector)

RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Gene ID

1827

Gene Name (Vector)

regulator of calcineurin 1

Gene Symbol

RCAN1

HGNC ID

HGNC:3040

ORF Size (aa)

594

RefSeq ID

NM_004414

RefSeq Synonyms

NM_203418, NM_203417, NM_004414, NM_001331016, NM_001285393, NM_001285392, NM_001285391, NM_001285389, BC002864,

Species

human

UniGene ID

Hs.282326

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.