human RASGRP1 Over-expression AAV

Name 
AAV-h-RASGRP1
Cat No 
AAV-220778
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RASGRP1.

AAV-220778
AAV-h-RASGRP1

Ready-to-use AAV expressing Human RASGRP1 (RAS guanyl releasing protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; V
Description (Vector)
RASGRP1 is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Gene ID
10125
Gene Name (Vector)
RAS guanyl releasing protein 1
Gene Symbol
RASGRP1
HGNC ID
HGNC:9878
ORF Size (aa)
2394
ORF Size (bp)
2394 bp
RefSeq ID
NM_005739
RefSeq Synonyms
NM_005739, NM_001306086, NM_001128602, BC109297, BC109296,
Species
human
UniGene ID
Hs.591127

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.