human RAPGEF6 Over-expression AAV

Name 
AAV-h-RAPGEF6
Cat No 
AAV-220740
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RAPGEF6.

AAV-220740
AAV-h-RAPGEF6

Ready-to-use AAV expressing Human RAPGEF6 (Rap guanine nucleotide exchange factor 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
KIA001LB; PDZ domain containing guanine nucleotide exchange factor (GEF) 2; PDZ domain-containing guanine nucleotide exchange factor 2; PDZ domain-containing guanine nucleotide exchange factor I; PDZGEF2; PDZ-GEF2; RAGEF2; RA-GEF-2; Rap guanine nucleotide exchange factor (GEF) 6; rap guanine nucleotide exchange factor 6
Description (eCommerce)
PDZ-GEF2 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity. PDZ-GEF2 has been shown to activate Rap1A and Rap1B to promote the maturation of cell-cell adherens junctions.
Gene ID
51735
Gene Name (eCommerce)
Rap guanine nucleotide exchange factor 6
Gene Name (Vector)
Rap guanine nucleotide exchange factor 6
Gene Symbol
RAPGEF6
HGNC ID
HGNC:20655
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2484
ORF Size (bp)
2484 bp
Protein Name (eCommerce)
Rap guanine nucleotide exchange factor 6
RefSeq ID
NM_016340
RefSeq Synonyms
NM_016340, NM_001164390, NM_001164389, NM_001164388, NM_001164387, NM_001164386, BC144627, BC142964, BC140820, BC133703,
Research Areas
Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology
Species
human
Target Sentence
PDZ-GEF2 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity. PDZ-GEF2 has been shown to activate Rap1A and Rap1B to promote the maturation of cell-cell adherens junctions.
UniGene ID
Hs.483329
UniProt ID (eCommerce)
Q8TEU7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.