human RANGAP1 Over-expression AAV

Name 
AAV-h-RANGAP1
Cat No 
AAV-220709
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RANGAP1.

AAV-220709
AAV-h-RANGAP1

Ready-to-use AAV expressing Human RANGAP1 (Ran GTPase activating protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Fug1; ran GTPase-activating protein 1; RANGAP; RanGAP1; SD; segregation distorter homolog; segregation distortion
Description (eCommerce)
The regulation of GTPase activity is achieved via activators called GEFs (guanine-nucleotide exchange factors) and inactivators called GAPs (GTPase-activating proteins). Ran-specific GTPase-activating protein 1 (RanGAP1) induces the GTPase activity of the RAN small GTPase. The Ran GTPase plays a role in spatial information and nucleocytoplasmic transport. RanGAP1 is the antagonist of the GEF RCC1 which keeps RAN in the active GTP-bound state.
Description (Vector)
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
Gene ID
5905
Gene Name (eCommerce)
Ran GTPase activating protein 1
Gene Name (Vector)
Ran GTPase activating protein 1
Gene Symbol
RANGAP1
HGNC ID
HGNC:9854
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1764
ORF Size (bp)
1764 bp
Protein Name (eCommerce)
Ran GTPase-activating protein 1
RefSeq ID
NM_002883
RefSeq Synonyms
NM_002883, NM_001317930, NM_001278651, BC041396, BC014044,
Research Areas
Cell Cycle,Cytoskeleton,Host-Virus Interactions,RNA Transport,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
The regulation of GTPase activity is achieved via activators called GEFs (guanine-nucleotide exchange factors) and inactivators called GAPs (GTPase-activating proteins). Ran-specific GTPase-activating protein 1 (RanGAP1) induces the GTPase activity of the RAN small GTPase. The Ran GTPase plays a role in spatial information and nucleocytoplasmic transport. RanGAP1 is the antagonist of the GEF RCC1 which keeps RAN in the active GTP-bound state.
UniGene ID
Hs.183800
UniProt ID (eCommerce)
P46060

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.