human QPRT Over-expression AAV

Name
AAV-h-QPRT

Cat No
AAV-220469

Availability
4-5 weeks

This is an AAV expressing Human QPRT.

AAV-220469

AAV-h-QPRT

Ready-to-use AAV expressing Human QPRT (quinolinate phosphoribosyltransferase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HEL-S-90n; QPRTase

Description (Vector)

QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Gene ID

23475

Gene Name (Vector)

quinolinate phosphoribosyltransferase

Gene Symbol

QPRT

HGNC ID

HGNC:9755

ORF Size (aa)

894

RefSeq ID

NM_014298

RefSeq Synonyms

NM_014298, NM_001318250, NM_001318249, BC018910, BC010033, BC005060,

Species

human

UniGene ID

Hs.513484

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.