human PTAFR Over-expression AAV

Name 
AAV-h-PTAFR
Cat No 
AAV-220203
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PTAFR.

AAV-220203
AAV-h-PTAFR

Ready-to-use AAV expressing Human PTAFR (platelet activating factor receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PAFR
Description (Vector)
PTAFR encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
Gene ID
5724
Gene Name (Vector)
platelet activating factor receptor
Gene Symbol
PTAFR
HGNC ID
HGNC:9582
ORF Size (aa)
1029
ORF Size (bp)
1029 bp
RefSeq ID
NM_000952
RefSeq Synonyms
NM_001164723, NM_001164722, NM_001164721, NM_000952, BC063000, BC013816,
Species
human
UniGene ID
Hs.709174

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.