human PSMD5 Over-expression AAV

Name 
AAV-h-PSMD5
Cat No 
AAV-220165
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PSMD5.

AAV-220165
AAV-h-PSMD5

Ready-to-use AAV expressing Human PSMD5 (proteasome 26S subunit, non-ATPase 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
26S protease subunit S5 basic; 26S proteasome non-ATPase regulatory subunit 5; 26S proteasome subunit S5B; proteasome (prosome, macropain) 26S subunit, non-ATPase, 5; S5B
Description (eCommerce)
PSMD5/26S Proteasome Subunit S5B acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16401].
Description (Vector)
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly.
Gene ID
5711
Gene Name (eCommerce)
proteasome 26S subunit, non-ATPase 5
Gene Name (Vector)
proteasome 26S subunit, non-ATPase 5
Gene Symbol
PSMD5
HGNC ID
HGNC:9563
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1515
ORF Size (bp)
1515 bp
Protein Name (eCommerce)
26S proteasome non-ATPase regulatory subunit 5
RefSeq ID
NM_005047
RefSeq Synonyms
NM_005047, NM_001270427, BC014478,
Research Areas
Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Neurobiology,Neurodegeneration,NF-kB Signaling,Notch Signaling,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Proteasome,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Wnt Signaling
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,signal_transduction,neurobiology,immunology,developmental_biology,neurobiology,cell_biology,genetics,transcription_translation,signal_transduction,immunology,signal_transduction,developmental_biology
Species
human
Target Sentence
PSMD5/26S Proteasome Subunit S5B acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16401].
UniGene ID
Hs.193725
UniProt ID (eCommerce)
Q16401

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.