human PSMD4 Over-expression AAV
This is an AAV expressing Human PSMD4.
AAV-220163
AAV-h-PSMD4
Ready-to-use AAV expressing Human PSMD4 (proteasome 26S subunit, non-ATPase 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; AF; AF-1; angiocidin; antisecretory factor 1; ASF; MCB1; multiubiquitin chain-binding protein; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; pUB-R5; Rpn10; S5A; S5a/antisecretory factor protein
Description (eCommerce)
PSMD4 [proteasome (prosome, macropain) 26S subunit, non-ATPase, 4] is a non-ATPase subunit of the 19S regulator lid. The 19S regulator and 20S core complexes make up the 26S proteasome which is a multicatalytic proteinase complex with a highly ordered structure. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides [taken from NCBI Entrez Gene (Gene ID: 5710)].
Description (Vector)
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.
Gene ID
5710
Gene Name (eCommerce)
proteasome 26S subunit, non-ATPase 4
Gene Name (Vector)
proteasome 26S subunit, non-ATPase 4
Gene Symbol
PSMD4
HGNC ID
HGNC:9561
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1134
Protein Name (eCommerce)
26S proteasome non-ATPase regulatory subunit 4
RefSeq ID
NM_002810
RefSeq Synonyms
NM_002810, NM_001330692, BC072008, BC002365,
Research Areas
Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Cell Division,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,NF-kB Signaling,Notch Signaling,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Proteasome,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,signal_transduction,metabolism,neurobiology,signal_transduction,immunology,developmental_biology,neurobiology,cell_biology,genetics,transcription_translation,signal_transduction,immunology,genetics,developmental_biology
Species
human
Target Sentence
PSMD4 [proteasome (prosome, macropain) 26S subunit, non-ATPase, 4] is a non-ATPase subunit of the 19S regulator lid. The 19S regulator and 20S core complexes make up the 26S proteasome which is a multicatalytic proteinase complex with a highly ordered structure. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides [taken from NCBI Entrez Gene (Gene ID: 5710)].
UniGene ID
Hs.505059
UniProt ID (eCommerce)
P55036
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.