human PSMA5 Over-expression AAV

Name 
AAV-h-PSMA5
Cat No 
AAV-220102
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PSMA5.

AAV-220102
AAV-h-PSMA5

Ready-to-use AAV expressing Human PSMA5 (proteasome subunit alpha 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
epididymis tissue sperm binding protein Li 11n; macropain subunit zeta; macropain zeta chain; multicatalytic endopeptidase complex zeta chain; proteasome (prosome, macropain) subunit, alpha type, 5; proteasome alpha 5 subunit; proteasome component 5; proteasome subunit alpha type-5; proteasome subunit zeta; proteasome zeta chain; PSC5; ZETA
Description (eCommerce)
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSAM5 is member of the peptidase T1A family and is an alpha subunit of the 20S core [taken from NCBI Entrez Gene (GeneID: 5684)].
Description (Vector)
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene.
Gene ID
5686
Gene Name (eCommerce)
proteasome subunit alpha 5
Gene Name (Vector)
proteasome subunit alpha 5
Gene Symbol
PSMA5
HGNC ID
HGNC:9534
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
726
Protein Name (eCommerce)
Proteasome subunit alpha type-5
RefSeq ID
NM_002790
RefSeq Synonyms
NM_002790, NM_001199774, NM_001199773, NM_001199772, BC103751, BC102020, BC102019, BC102018,
Research Areas
Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,NF-kB Signaling,Notch Signaling,Proteasome,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,signal_transduction,developmental_biology,cell_biology,genetics,transcription_translation,signal_transduction,immunology,genetics,developmental_biology
Species
human
Target Sentence
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSAM5 is member of the peptidase T1A family and is an alpha subunit of the 20S core [taken from NCBI Entrez Gene (GeneID: 5684)].
UniGene ID
Hs.712557
UniProt ID (eCommerce)
P28066

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.