human PRPF31 Over-expression AAV

Name 
AAV-h-PRPF31
Cat No 
AAV-219952
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PRPF31.

AAV-219952
AAV-h-PRPF31

Ready-to-use AAV expressing Human PRPF31 (pre-mRNA processing factor 31). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hPrp31; NY-BR-99; Pre-mRNA-processing factor 31; protein 61K; PRP31; PRP31 pre-mRNA processing factor 31 homolog; RP11; serologically defined breast cancer antigen NY-BR-99; SNRNP61; U4/U6 small nuclear ribonucleoprotein Prp31; U4/U6 snRNP 61 kDa protein
Description (eCommerce)
Pre-mRNA-processing factor 31 (PRPF31) is involved in pre-mRNA splicing and is required for U4/U6.U5 tri-snRNP formation. Defects in the PRPF31 gene are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8WWY3].
Description (Vector)
PRPF31 encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.
Gene ID
26121
Gene Name (eCommerce)
pre-mRNA processing factor 31
Gene Name (Vector)
pre-mRNA processing factor 31
Gene Symbol
PRPF31
HGNC ID
HGNC:15446
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1500
ORF Size (bp)
1500 bp
Protein Name (eCommerce)
U4/U6 small nuclear ribonucleoprotein Prp31
RefSeq ID
NM_015629
RefSeq Synonyms
NM_015629, BC117389,
Research Areas
Gene Expression,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Pre-mRNA-processing factor 31 (PRPF31) is involved in pre-mRNA splicing and is required for U4/U6.U5 tri-snRNP formation. Defects in the PRPF31 gene are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8WWY3].
UniGene ID
Hs.515598
UniProt ID (eCommerce)
Q8WWY3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.