human PRKAA2 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-219832
Availability:
3-5 weeks
Name:
AAV-h-PRKAA2
This is an AAV expressing Human PRKAA2.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- PRKAA2
- Gene Name
- protein kinase AMP-activated catalytic subunit alpha 2
- Gene ID
- 5563
- Gene Synonyms
- AMPK; AMPK2; AMPKa2; PRKAA
- ORF Size
- 1659 bp
- RefSeq#
- BC069680
- Gene Description
- PRKAA2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
- UniGene ID
- Hs.437039
- HGNC ID
- HGNC:9377
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