human PPP2R5D Over-expression AAV

Name 
AAV-h-PPP2R5D
Cat No 
AAV-219669
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PPP2R5D.

AAV-219669
AAV-h-PPP2R5D

Ready-to-use AAV expressing Human PPP2R5D (protein phosphatase 2 regulatory subunit B’delta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
B56D; B56delta; MRD35; PP2A B subunit isoform B56-delta; PP2A B subunit isoform B'-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; protein phosphatase 2, regulatory subunit B (B56), delta isoform; Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Description (eCommerce)
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. It is a trimeric holoenzyme that is comprised of a catalytic, structural, and regulatory subunit. PPP2R5D is a regulatory subunit of PP2A. The regulatory subunits of PP2A are grouped into 3 families: B/PR55, B’/PR61, and B’’/PR72. PPP2R5D encodes the delta isoform of the B’ subunit, B56. PPP2R5D may function to localize PP2A to the nucleus. serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, PP2A B subunit B’ delta isoform, PP2A B subunit B56 delta isoform, PP2A B subunit PR61 delta isoform, PP2A B subunit R5 delta isoform, B56D, MGC2134, MGC8949.
Description (Vector)
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
5528
Gene Name (eCommerce)
protein phosphatase 2 regulatory subunit B'delta
Gene Name (Vector)
protein phosphatase 2 regulatory subunit B'delta
Gene Symbol
PPP2R5D
HGNC ID
HGNC:9312
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1713
ORF Size (bp)
1713 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
RefSeq ID
NM_006245
RefSeq Synonyms
NM_180977, NM_180976, NM_006245, NM_001270476, BC010692, BC001175, BC001095,
Research Areas
Alzheimer's Disease,Cell Cycle,GPCR Signaling,Immunology,Innate Immunity,Kinase/Phosphatase,MAPK Signaling,Meiosis,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,Neurodegeneration,Neurodevelopment,NGF Signaling,Notch Signaling,PI3K/Akt Signaling,Signal Transduction,Toll-like Receptor Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. It is a trimeric holoenzyme that is comprised of a catalytic, structural, and regulatory subunit. PPP2R5D is a regulatory subunit of PP2A. The regulatory subunits of PP2A are grouped into 3 families: B/PR55, B’/PR61, and B’’/PR72. PPP2R5D encodes the delta isoform of the B’ subunit, B56. PPP2R5D may function to localize PP2A to the nucleus. serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, PP2A B subunit B’ delta isoform, PP2A B subunit B56 delta isoform, PP2A B subunit PR61 delta isoform, PP2A B subunit R5 delta isoform, B56D, MGC2134, MGC8949.
UniGene ID
Hs.533308
UniProt ID (eCommerce)
Q14738

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.