human PPFIBP1 Over-expression AAV

Name
AAV-h-PPFIBP1

Cat No
AAV-219532

Availability
4-5 weeks

This is an AAV expressing Human PPFIBP1.

AAV-219532

AAV-h-PPFIBP1

Ready-to-use AAV expressing Human PPFIBP1 (PPFIA binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

hSGT2; hSgt2p; L2; liprin related protein; liprin-beta-1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; protein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1; PTPRF interacting protein, binding protein 1 (liprin beta 1); PTPRF-interacting protein-binding protein 1; SGT2

Description (eCommerce)

Liprin beta 1 is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. Liprin beta 1 was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiments demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2 [taken from NCBI Entrez Gene (Gene ID: 8496)].

Description (Vector)

PPFIBP1 is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene ID

8496

Gene Name (eCommerce)

PPFIA binding protein 1

Gene Name (Vector)

PPFIA binding protein 1

Gene Symbol

PPFIBP1

HGNC ID

HGNC:9249

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3036

ORF Size (bp)

3036 bp

Protein Name (eCommerce)

Liprin-beta-1

RefSeq ID

NM_003622

RefSeq Synonyms

NM_177444, NM_003622, NM_001198916, NM_001198915, BC050281,

Research Areas

Cell Biology

Research Areas (Faceted)

cell_biology

Species

human

Target Sentence

UniGene ID

Hs.172445

UniProt ID (eCommerce)

Q86W92

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.